- 2008 – People’s Choice Awards – Favorite Daytime Talk Show Host, Favorite Funny Female Star
- 2007 – Daytime Emmy Awards – Best Talk Show Host, Outstanding Talk Show
- 2007 – People’s Choice Awards – Favorite Daytime Talk Show Host, Favorite Funny Female Star
- 2006 – Daytime Emmy Awards – Best Talk Show Host, Outstanding Talk Show
- 2006 – People’s Choice Awards – Favorite Daytime Talk Show Host, Favorite Funny Female Star
- 2005 – Daytime Emmy Awards – Best Talk Show Host, Outstanding Talk Show
- 2005 – People’s Choice Awards – Favorite Daytime Talk Show Host, Favorite Funny Female Star
- 2004 – Daytime Emmy Award – Outstanding Talk Show (The Ellen DeGeneres Show)
- 2004 – Kid’s Choice Award – Favorite Voice from an Animated Movie (Finding Nemo)
- 2001 – American Comedy Award – Funniest Female Performer in a TV Special (Ellen DeGeneres: The Beginning)
- 1997 – Emmy Award – Outstanding Writing for a Comedy Series (Ellen – “The Puppy Episode”)
- 1995 – American Comedy Award – Funniest Female Performer in a TV Special
(Moderation The 46th Annual Primetime Emmy Awards) - 1991 – American Comedy Award – Funniest Female Stand-Up Comic